*Sucralfate 1 g tablet
For the treatment of peptic ulcer diseases, chronic gastritis and for prophylaxis of gastrointestinal haemorrhage from stress ulceration
Box of 30 Tablets
*Sucralfate is used for the treatment of peptic ulcer disease and to prevent recurrent ulcers after healing of the ulcer has been achieved. It also has been used to relieve or prevent ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs) but is less effective thanmisoprostol (Cytotec). Sucralfate also is used in the treatment of patients with gastroesophageal reflux disease (GERD) and to prevent ulcers associated with high degrees of physical stress (for example, extensiveburns, surgery, and overwhelming infection) in hospitalized patients.
*Sucralfate is a unique oral drug. Chemically, it is a complex of the disaccharide sugar, sucrose, combined with sulfate and aluminum. It is minimally absorbed into the body, and its actions are entirely on the lining of the stomach and duodenum. Although its mechanism of action is not entirely understood, the following actions are thought to be important for its beneficial effects.
*Sucralfate binds to the surface of ulcers (attaching to exposed proteins) and coats the ulcer, thus protecting the ulcer surface to some extent from further injury by acid and pepsin;
*Sucralfate directly inhibits pepsin (an enzyme that breaks apart proteins) in the presence of stomach acid;
*Sucralfate binds bile salts coming from the liver via the bile thus protecting the stomach lining from injury caused by the bile acids;
*Sucralfate may increase prostaglandin production, and prostaglandins are known to protect the lining of the stomach.
The recommended dose for treatment of active ulcers is 1 gram four times daily for 4-8 weeks. Sucralfate is administered on an empty stomach, at least one hour prior to meals, for best results. The dose for preventing recurrent ulcers is 1 gram twice daily.